Endocrine Abstracts

Introduction: Although the etiology of osteoporosis is different between men and women, the underlying pathophysiologic mechanism is similar, namely an absolute or relative increase in bone resorption, leading to progressive bone loss. Transforming growth factor (TGF) beta-1 is a growth factor in human bone, which is produced by osteoblasts and inhibits osteoclast proliferation and activity and stimulates proliferation and differentiation of preosteoblasts.<p class="abstex...

Acromegaly is associated with cardiovascular diseases. Accelerated atherosclerosis may have important role in that. The aim of this study was to examine the presence of dyslipidemia, glucose control imapairment, inflamation and hypertension as risk factors for the development of atherosclerosis in acromegalic patients.Study group included 28 patients with acromegaly without lesions of thyroid, adrenal and gonadal axis. The examination was performed befor...

A child with short stature having height greater than 2 standard deviations below the mean for age and bone age delay of two years but with normal growth hormone secretion tests was identified. Since there was no known clinical cause of the short stature, it was decided to sequence both alleles of the patient's GH1 gene that encodes pituitary GH to determine whether there was a genetic defect responsible for the observed phenotype (with local ethical approval). A 3.2kb fragmen...

The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic infl...

Objective: To characterize the age variations of fatness pattern in Spanish womenResearch methods and procedures:: A cross-sectional study of 2226 Spanish women (16 to 74 years old) women was undertaken to study age variations in adiposity, body composition, obesity and central fat distribution. The women were divided into seven groups: Group I (G I, 15–24 years), Group II (G II, 25–34 years), Group III (G III, 35–44 years), Group IV (G IV...

Introduction: Recent data suggest a reciprocal influence between bone and energy metabolism. Mediators have been identified as osteocalcin (OC), which stimulates insulin (IRI) secretion and activity and IRI as bone anabolic factor. Primary hyperparathyroidism (PHPT) stimulates bone turnover, induces osteoporosis and is associated with increased IRI resistance. A positive relationship between OC and IRI sensitivity has been found in PHPT, but no data exist on the relationship b...

Context: Estrogens may have protective properties in the cardiovascular system, linked to the activation of estrogen receptor alpha (ERα), present in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). ERα-mediated signaling regulates vasodilatation and atherogenesis, and since hypertension and atherosclerosis are major mechanisms in stroke development, we hypothesized that genetic variations in the ERα gene (ESR1) were associated with strok...

IntroductionLow Bone Mineral Density (BMD) is highly prevalent in adults with cystic fibrosis (CF) and is associated with increased fracture rates. We sought to establish how BMD changes with time in adults with CF and to determine what factors influence this change.MethodsA retrospective analysis of interval bone densitometry using Dual Energy X-ray Absorptiometry (DXA) scanning in 86 adults with CF was unde...

Prolactinomas are the most common secreting pituitary tumors. Although most respond well to dopamine agonists, some prolactinomas are dopamine-resistant and very aggressive. Here we present a 37-year-old patient with aggressive prolactinoma.Case report: The 37-year-old patient was referred to the University Hospital Centre Zagreb in March 2020 for bilateral visual field defects and headaches due to prolactinoma. In 2017, he had a transsphenoidal resectio...

Issues: Adolescent diabetes social stigma in India. Such diabetics needs proper guidance/information/treatment-counselling outlets. This is burning issue in developing-nations like India. Hence we all need to unite & form a comprehensive diabetes care & counselling policy plan at ECE conference. Treatment options must be suitable for developing-nations considering cost of Rx. Incorporating NGO’s in such efforts is very effective.Our Project ...